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2025 AHA Guidelines Update: What Changed for ACLS

Chicago's Pulse February 03, 2026 ACLS

The American Heart Association released updated guidelines affecting ACLS protocols. Here's what healthcare providers need to know about the changes to cardiac arrest management.

The American Heart Association periodically updates its guidelines based on the latest resuscitation science. The most recent updates include several important changes that affect ACLS providers.

Emphasis on High-Quality CPR

The updated guidelines continue to reinforce that high-quality chest compressions are the single most important intervention during cardiac arrest. This means adequate depth, rate, full recoil, and minimal interruptions — principles that should drive every decision during a code.

Updated Epinephrine Timing

For non-shockable rhythms (PEA/asystole), the guidelines continue to recommend early administration of epinephrine. For shockable rhythms (VF/pVT), epinephrine should be administered after the initial defibrillation attempts. The emphasis on timing reflects research showing that early epi in non-shockable rhythms improves outcomes.

Double Sequential Defibrillation

There is growing interest in double sequential defibrillation (using two defibrillators simultaneously) for refractory VF. While not yet a formal AHA recommendation, some systems are studying this approach, and it's a topic ACLS providers should be aware of.

Post-Cardiac Arrest Care

The guidelines reinforce the importance of targeted temperature management (TTM) for comatose patients after return of spontaneous circulation (ROSC). The target temperature and duration continue to be studied, but the principle of avoiding hyperthermia and managing temperature actively remains standard.

Team-Based Resuscitation

Updated guidelines place even greater emphasis on team dynamics, closed-loop communication, and the role of the team leader in coordinating an effective resuscitation effort.

Stay Current

Healthcare providers should ensure their ACLS certification reflects the latest guidelines. At Chicago's Pulse, our ACLS courses always incorporate the most current AHA science and protocols.

Content may be AI-assisted. All information reflects the views of Chicago's Pulse, an AHA-Authorized Training Center, and should be independently verified before making clinical or compliance decisions. For emergency medical situations, call 911.